Recent Advances in Divergent Synthetic Strategies for Indole-Based Natural Product Libraries
Taegwan Kim1,2, Min Woo Ha3,4, Jonghoon Kim1,2
1Department of Chemistry, Soongsil University, 369 Sangdo-ro, Seoul 06978, Korea.
Abstract:
Considering the potential bioactivities of natural product and natural product-like compounds with highly complex and diverse structures, the screening of collections and small-molecule libraries for high-throughput screening (HTS) and high-content screening (HCS) has emerged as a powerful tool in the development of novel therapeutic agents. Herein, we review the recent advances in divergent synthetic approaches such as complexity-to-diversity (Ctd) and biomimetic strategies for the generation of structurally complex and diverse indole-based natural product and natural product-like small-molecule libraries.
Related Concept Videos
Drug Discovery: Overview
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry
Synthetic Biology
Golden rice
Golden rice is a genetically modified...
Diels–Alder Reaction: Characteristics of Dienes
Characteristics of the diene
Conformation
The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is...
Inductive Effects on Chemical Shift: Overview
Genetic Screens
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...


