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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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MicroRNAs in Leukemias: A Clinically Annotated Compendium.

Aleksander Turk1, George A Calin2, Tanja Kunej1

  • 1Department of Animal Science, Biotechnical Faculty, University of Ljubljana, 1230 Domžale, Slovenia.

International Journal of Molecular Sciences
|April 12, 2022
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are key regulators in leukemia. This study identified central miRNAs and their target genes, revealing interconnected networks crucial for understanding leukemia and developing new therapies.

Keywords:
interaction networkleukemiamiRNA-target interaction (MTI)microRNA (miRNA)

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Area of Science:

  • Hematology
  • Molecular Biology
  • Genetics

Background:

  • Leukemias are blood and bone marrow cancers with limited treatment options and frequent relapses.
  • MicroRNAs (miRNAs) are noncoding RNAs involved in gene regulation and show promise as novel therapeutic targets for leukemia.

Purpose of the Study:

  • To identify central microRNAs (miRNAs) and their target genes associated with multiple leukemia types.
  • To analyze miRNA-target interactions (MTIs) and their potential as therapeutic targets in leukemia.

Main Methods:

  • Data synthesis from miRTarBase and DISNOR databases to identify leukemia-associated miRNAs and genes.
  • Construction and visualization of miRNA-target interaction (MTI) networks.
  • Manual literature review of identified MTIs in leukemia models.
  • Compilation of leukemia clinical trials.

Main Results:

  • A network of 248 miRNA-target interactions (MTIs) was formed, with 64 MTIs manually curated from literature.
  • Key miRNAs identified include miR-125b-5p, miR-155-5p, miR-181a-5p, and miR-19a-3p.
  • Significant target genes include TP53, BCL2, KIT, ATM, RUNX1, and ABL1, forming a highly interconnected network.

Conclusions:

  • The interconnectedness of the MTI network suggests that specific miRNAs act as central regulators across multiple leukemia types.
  • Further research into miRNAs, their targets, and pathways is essential to unlock their therapeutic potential in leukemia treatment.