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Published on: January 25, 2017
The Role of IL-22 in Wound Healing. Potential Implications in Clinical Practice
Roxana Delia Zaharie1,2, Călin Popa3,4, Diana Schlanger3,4
1Gastroenterology Department, "Iuliu Haţieganu" University of Medicine and Pharmacy, Street Emil Isac No. 13, 400023 Cluj-Napoca, Romania.
Abstract:
Wound healing is a complex process that is mediated and influenced by several cytokines, chemokines, and growth factors. Interleukin-22 (IL-22) is a cytokine that plays a critical role in tissue regeneration. Our study is a systematic review that addressed the implications of IL-22 in the healing of wounds caused by external factors. Thirteen studies were included in our review, most of them being experimental studies. Three clinical studies underlined the potential role of IL-22 in day-to-day clinical practice. IL-22 plays a central role in wound healing, stimulating the proliferation, migration, and differentiation of the cells involved in tissue repair. However, overexpression of IL-22 can cause negative effects, such as keloid scars or peritoneal adhesions. The results of the presented studies are promising, but further research that validates the roles of IL-22 in clinical practice and analyzes its potential implication in surgical healing is welcomed.
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