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Related Concept Videos

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Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
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Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
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Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
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Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
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Introduction
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Related Experiment Video

Updated: Sep 27, 2025

The Effect of Anti-Fatigue Decoction on the Behaviors and Serological Indicators in a Central Fatigue Rat Model
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Central and Peripheral Fatigue in Physical Exercise Explained: A Narrative Review.

José Francisco Tornero-Aguilera1,2, Jorge Jimenez-Morcillo1, Alejandro Rubio-Zarapuz1,2

  • 1Faculty of Sports Sciences, Universidad Europea de Madrid, Tajo Street, s/n, 28670 Madrid, Spain.

International Journal of Environmental Research and Public Health
|April 12, 2022
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Summary

Understanding exercise fatigue is crucial for training prescription. This review explores the multifactorial origins of fatigue, including psychological and physiological elements, to inform better training strategies.

Keywords:
cognitiongendermuscle activationmuscle fatiguepsychophysiology

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Area of Science:

  • Exercise Physiology
  • Sports Science
  • Human Performance

Background:

  • Exercise-induced fatigue is complex and multifactorial, necessitating a deeper understanding for effective training load prescription.
  • Current knowledge gaps hinder optimal guidance for athletes and clinical populations.
  • Fatigue mechanisms are not fully elucidated, impacting training and rehabilitation strategies.

Purpose of the Study:

  • To conduct a narrative review analyzing the multifactorial factors contributing to fatigue during physical exercise.
  • To synthesize current understanding of central and peripheral fatigue mechanisms.
  • To highlight the influence of psychological and physiological factors on exercise capacity.

Main Methods:

  • A consensus and critical review of primary (scientific articles) and secondary (indexes, databases, web pages) sources.
  • Searches conducted across major scientific databases including PubMed, SciELO, and Google Scholar.
  • Analysis focused on the Integrative Governor theory and its implications for fatigue.

Main Results:

  • Central and peripheral fatigue are integrated components of the Integrative Governor theory, governed by homeostatic principles.
  • Fatigue manifestation is influenced by individual factors such as gender, sleep status, and psychological state (e.g., stress).
  • Non-physiological factors, including psychological disturbances, significantly impact neural activation and cognitive function during fatigue.

Conclusions:

  • A comprehensive understanding of fatigue requires considering both physiological and psychological dimensions.
  • Future approaches in sports and clinical settings must integrate these multifactorial aspects for effective interventions.
  • Recognizing the diverse origins of fatigue is essential for personalized training and recovery protocols.