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Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Related Experiment Video

Updated: Sep 27, 2025

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

Tracking down tumor-specific T cells.

James Reading¹, Kane Foster², Kroopa Joshi³

¹Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.

|April 12, 2022

Summary

This summary is machine-generated.

Single-cell sequencing precisely identifies tumor-specific T cells by defining their unique molecular phenotype. This advance offers new strategies for cancer immunotherapy development.

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Area of Science:

Immunology
Genomics
Oncology

Background:

Tumor-specific T cells are crucial for effective cancer immunity.
Identifying these cells is challenging due to their rarity and heterogeneity.

Purpose of the Study:

To demonstrate how single-cell sequencing can define molecular phenotypes for tumor-specific T cells.
To highlight advancements in cancer immunotherapy research.

Main Methods:

Utilized single-cell sequencing techniques.
Analyzed gene expression profiles to identify distinct T cell populations.

Main Results:

Successfully defined molecular phenotypes that distinguish tumor-specific T cells.
Provided a method for precise identification of these critical immune cells.

Conclusions:

Single-cell sequencing is a powerful tool for characterizing tumor-specific T cells.
These findings pave the way for improved cancer immunotherapies.