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Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

3.0K
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

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Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
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Types of Fever01:25

Types of Fever

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Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
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Decreased Body Temperature01:29

Decreased Body Temperature

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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Methods of reducing fever01:22

Methods of reducing fever

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The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
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Factors Affecting Body Temperature01:28

Factors Affecting Body Temperature

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As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may  include:
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Related Experiment Video

Updated: Sep 27, 2025

Protocol for Long Duration Whole Body Hyperthermia in Mice
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Malignant Hyperthermia: A Killer If Ignored.

Xin Bin1, Baisheng Wang2, Zhangui Tang2

  • 1Oral and Maxillofacial Surgery Department, Xiangya School of Stomatology, Central South University, Changsha, Hunan, China.

Journal of Perianesthesia Nursing : Official Journal of the American Society of Perianesthesia Nurses
|April 13, 2022
PubMed
Summary

Malignant hyperthermia (MH) is a severe, inherited muscle disorder triggered by certain factors. Early recognition and dantrolene treatment are crucial for patient survival.

Keywords:
anesthesiacalcium channelmalignant hypothermiarisk factorstreatment principle

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Area of Science:

  • Anesthesiology
  • Genetics
  • Pharmacology

Background:

  • Malignant hyperthermia (MH) is a life-threatening hypermetabolic skeletal muscle response.
  • It is an autosomal dominant condition linked to mutations in RYR1, CACNA1S, or STAC3 genes, affecting calcium release channels.
  • While global incidence varies (1:5,000-1:250,000), Chinese national statistics are lacking, and potential racial/regional differences are unknown.

Purpose of the Study:

  • To provide an overview of Malignant hyperthermia (MH).
  • To discuss triggers, clinical presentation, diagnosis, and management of MH.
  • To highlight the importance of prompt intervention and the "5C principles" algorithm.

Main Methods:

  • Review of existing literature on Malignant hyperthermia (MH).
  • Discussion of diagnostic tools including medical/family history, clinical signs, in vitro caffeine-halothane contracture testing (IVCT/CHCT), and genetic testing.
  • Emphasis on clinical management strategies.

Main Results:

  • MH can be triggered by anesthetics, strenuous exercise, heatstroke, and emotional stress.
  • Viral infections, statins, hyperglycemia, and muscle metabolic issues may accelerate onset.
  • Key preclinical signs include masseter muscle rigidity, elevated end-tidal carbon dioxide, and rapid temperature increase.

Conclusions:

  • Prompt cessation of triggers, professional support, and dantrolene administration are critical upon suspected MH onset.
  • The "5C principles" offer a structured approach for symptomatic treatment.
  • Further research into MH incidence in China and potential demographic variations is warranted.