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Updated: May 7, 2026
Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
Published on: September 2, 2015
(K,Na)NbO3-based lead-free ceramic/polyvinylidene fluoride piezoelectric composite for biomimetic wound healing via
Linfeng Fan1, Zhiyuan Dai2, Xinna Bai3
1Department of Periodontics & Oral Mucosal Section, Xiangya Stomatological Hospital & Xiangya School of Stomatology, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Oral Health Research, Central South University, Changsha, Hunan, China.
Abstract:
Electrical stimulation that mimics endogenous electric fields represents a promising therapeutic strategy for wound healing. In this study, a lead-free piezoelectric composite film was fabricated by incorporating (K,Na)NbO3(KNN) ceramics into a polyvinylidene fluoride (PVDF) matrix via tape casting. The introduction of KNN fillers significantly enhanced the β-phase content and piezoelectric output of PVDF. Under ultrasound irradiation, the resulting KNN/PVDF film effectively promoted fibroblast proliferation and migration in vitro, achieving a 54.84% migration rate within 24 h and upregulating key wound-repair genes, including TGF-β and VEGF. In vivo, the composite film markedly accelerated the healing of full-thickness skin defects in rats, promoted neovascularization, and achieved approximately 95% wound closure by day 9. These results demonstrate that the KNN/PVDF composite film provides an effective wireless platform for biomimetic electrical stimulation in tissue regeneration.
