Uncommon presentation of Kikuchi disease

Area of Science:

• Medicine
• Pathology
• Immunology

Background:

• Kikuchi disease, also known as histiocytic necrotizing lymphadenitis, is an uncommon, benign, and self-limiting disorder.
• It predominantly affects young women of Asian descent, typically presenting with cervical lymphadenopathy and fever.
• While generally resolving spontaneously, Kikuchi disease can manifest with varied clinical presentations.

Purpose of the Study:

• To investigate the clinical presentation of Kikuchi disease in a male patient.
• To emphasize the importance of considering Kikuchi disease in the differential diagnosis of axillary lymphadenopathy, particularly in males.
• To contribute to the understanding of atypical presentations of Kikuchi disease.

Main Methods:

• Case report of a male patient diagnosed with Kikuchi disease.
• Review of clinical symptoms, diagnostic procedures, and histopathological findings.
• Comparison with existing literature on Kikuchi disease demographics and presentations.

Main Results:

• The patient presented with axillary lymphadenopathy as the primary symptom.
• Kikuchi disease was confirmed through histopathological examination.
• This presentation deviates from the typical demographic and symptomatic profile of the disease.

Conclusions:

• Axillary lymphadenopathy can be a significant presenting symptom of Kikuchi disease in males.
• Kikuchi disease should be included in the differential diagnosis for patients presenting with axillary lymphadenopathy, irrespective of typical demographic factors.
• Further research may elucidate the variations in clinical presentation across different genders and ethnicities.