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Updated: Sep 27, 2025

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
Published on: February 9, 2024
DNA nanomachine for visual detection of structured RNA and double stranded DNA
Daria A Gorbenko1,2, Liubov A Shkodenko1, Maria S Rubel1
1Laboratory of Molecular Robotics and Biosensor Materials, SCAMT Institute, ITMO University, Saint-Petersburg, Russia, 9 Lomonosova Str., St. Petersburg, 191002, Russian Federation. dmitry.kolpashchikov@ucf.edu.
Abstract:
Visual detection of ssRNA and dsDNA amplicons was achieved at room temperature without the need for a probe-analyte annealing stage. This approach uses a DNA nanostructure equipped with two analyte-binding arms. Highly selective binding of the third arm leads to the formation of a G-quadruplex structure capable of changing the solution color.
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