Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

35.4K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
35.4K
Pleiotropy01:33

Pleiotropy

41.3K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
41.3K
Meiosis I03:09

Meiosis I

41.7K
Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
41.7K
Epigenetic Regulation01:37

Epigenetic Regulation

3.2K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.2K
Aging01:26

Aging

217
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
217
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.7K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PUF60 is a Critical Regulator of PKM Splicing During Myogenesis.

Molecular and cellular biology·2026
Same author

RNA-dependent SFPQ condensates coordinate multidimensional regulation of extra-long neuronal genes.

Cell chemical biology·2026
Same author

Postmortem brain single-nucleus and bulk gene expression analyses identify shared and distinct abnormalities in bipolar disorder and major depressive disorder.

Translational psychiatry·2026
Same author

Multimodal intervention benefits: Responder analysis of J-MINT PRIME Kanagawa trial.

Archives of gerontology and geriatrics·2026
Same author

Ethanolamine as a potential biomarker and therapeutic target for depressive disorder.

Molecular psychiatry·2026
Same author

Japanese Cohort Study Identifies an Association Between the Serotonin Transporter-Linked Polymorphic Region and Suicide Death.

Neuropsychopharmacology reports·2026

Related Experiment Video

Updated: Sep 27, 2025

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

9.6K

Epigenetic aging in Williams syndrome.

Satoshi Okazaki1, Ryo Kimura2, Ikuo Otsuka1

  • 1Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.

Journal of Child Psychology and Psychiatry, and Allied Disciplines
|April 13, 2022
PubMed
Summary

Williams syndrome (WS) may accelerate biological aging, as indicated by epigenetic clocks like GrimAge and DNAm telomere length. Further research is needed to understand these aging effects and improve patient care.

Keywords:
AgingWilliams syndromeepigenetics

More Related Videos

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.4K
Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.2K

Related Experiment Videos

Last Updated: Sep 27, 2025

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan
11:58

The Replica Set Method: A High-throughput Approach to Quantitatively Measure Caenorhabditis elegans Lifespan

Published on: June 29, 2018

9.6K
A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
10:39

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae

Published on: September 17, 2020

6.4K
Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine
08:53

Author Spotlight: Automated Lifespan Monitoring – Discovering Aging Dynamics with the Lifespan Machine

Published on: January 26, 2024

1.2K

Area of Science:

  • Genetics
  • Epigenetics
  • Aging Research

Background:

  • Williams syndrome (WS) is a rare genetic disorder linked to 7q11.23 microdeletion, presenting diverse physical and cognitive symptoms.
  • Altered DNA methylation (DNAm) patterns are associated with WS, but long-term aging effects remain unclear.
  • Epigenetic clocks, using genome-wide DNAm profiles, can estimate biological aging and identify age-related markers.

Purpose of the Study:

  • To investigate epigenetic aging in Williams syndrome.
  • To compare epigenetic clocks, including GrimAge and DNAm-based telomere length (DNAmTL), between WS patients and healthy controls.

Main Methods:

  • Blood samples from 32 WS patients and 32 controls were analyzed.
  • Evaluated GrimAge, DNAmTL, and other epigenetic clocks.

Main Results:

  • WS patients exhibited significantly accelerated GrimAge, DNAmTL, and other epigenetic clocks compared to controls.
  • Altered levels of GrimAge components (adrenomedullin, GDF-15, leptin, PAI-1) were observed in WS patients.

Conclusions:

  • This study suggests Williams syndrome is associated with accelerated biological aging.
  • Understanding WS's biological effects can improve patient care; long-term studies are warranted.