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Related Experiment Video

Updated: Sep 27, 2025

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
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An evolutionary gap in primate default mode network organization.

Clément M Garin1, Yuki Hori2, Stefan Everling3

  • 1Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA; Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA; Université Paris-Saclay, CEA, CNRS, Laboratoire des Maladies Neurodégénératives, 92265 Fontenay-aux-Roses, France; Université Paris-Saclay, CEA, Molecular Imaging Research Center, 92265 Fontenay-aux-Roses, France.

Cell Reports
|April 13, 2022
PubMed
Summary
This summary is machine-generated.

The human default mode network (DMN) shows significant differences compared to non-hominoid primates. Key connectivity patterns, like the medial prefrontal cortex-posterior cingulate cortex link, are absent in these species.

Keywords:
BOLDCP: NeuroscienceDMNevolutionfMRImacaquemarmosetmedial prefrontal cortexmouse lemurprimatesresting-state

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Area of Science:

  • Neuroscience
  • Comparative Cognition
  • Primate Brain Evolution

Background:

  • The human default mode network (DMN) is crucial for self-referential thought and is active during rest.
  • Homologous cortical areas in primates are thought to form an equivalent network.
  • Understanding primate DMN organization offers insights into human cognitive evolution.

Purpose of the Study:

  • To compare the functional connectivity of the default mode network (DMN) across humans and non-hominoid primates.
  • To identify similarities and differences in DMN organization between species.
  • To investigate the evolutionary trajectory of the DMN and associated cognitive functions.

Main Methods:

  • Cross-species functional connectivity analysis of resting-state fMRI data.
  • Comparison of DMN connectivity profiles in humans, macaques, marmosets, and mouse lemurs.
  • Identification of distinct resting-state networks across species.

Main Results:

  • Major dissimilarities were found in DMN connectivity profiles between humans and non-hominoid primates.
  • The medial prefrontal cortex (mPFC) shows weak engagement with the posterior cingulate cortex (PCC) in non-hominoid primates, unlike in humans.
  • A fronto-temporal resting-state network involving the mPFC was consistently observed in non-hominoid primates.

Conclusions:

  • The primate DMN organization exhibits substantial interspecies variation, particularly between humans and non-hominoid primates.
  • The human DMN's unique connectivity, especially the mPFC-PCC link, may underpin distinct cognitive functions.
  • Evolutionary divergence has shaped the primate DMN, highlighting a gap in shared functional organization and cognitive abilities.