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Updated: Sep 27, 2025

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

The Small Round Cell Sarcomas Complexities and Desmoplastic Presentation.

Henryk A Domanski¹

¹Department of Clinical Genetics and Pathology, Laboratory Medicine Region Skåne, Lund, Sweden.

Acta Cytologica

|April 13, 2022

Summary

This summary is machine-generated.

Small round cell sarcomas (SRCSs) are common pediatric cancers with overlapping features. Accurate diagnosis of these bone and soft tissue tumors relies on combining fine needle aspiration (FNA) biopsy with ancillary tests, even for rare presentations.

Keywords:

Cytology Fine needle aspiration Round cell Sarcoma Soft tissue

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Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts

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Published on: June 13, 2019

Area of Science:

Oncology
Pathology
Pediatric Medicine

Background:

Small round cell sarcomas (SRCSs) represent a significant portion of pediatric solid malignancies.
These tumors exhibit heterogeneous clinical and overlapping microscopic features, complicating initial diagnosis.
SRCSs include entities like desmoplastic small round cell tumor, poorly differentiated synovial sarcoma, and alveolar rhabdomyosarcoma.

Purpose of the Study:

To review cytomorphologic criteria for small round cell sarcomas (SRCSs).
To highlight rare and divergent cytological features of SRCSs.
To emphasize the importance of ancillary tests in diagnosing SRCSs.

Main Methods:

Review of cytomorphologic criteria for SRCSs.
Analysis of clinical presentation, cytological features, immunohistochemical patterns, and molecular alterations.
Evaluation of fine needle aspiration (FNA) biopsy specimens in conjunction with ancillary tests.

Main Results:

SRCSs often require ancillary tests due to overlapping features.
Fine needle aspiration (FNA) biopsy, when combined with ancillary tests, enables accurate diagnosis in most cases.
Subtle cytologic features can narrow differential diagnoses and guide ancillary testing.

Conclusions:

Accurate diagnosis of SRCSs necessitates a comprehensive assessment of clinical, cytological, immunohistochemical, and molecular data.
Awareness of rare and divergent cytological findings is crucial to prevent misdiagnosis.
The role of FNA biopsy in diagnosing bone and soft tissue tumors is increasingly vital, supported by ancillary testing.