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Chronic Inflammatory Orbitopathy Hiding Orbital Lymphoma
Samah Tahri1, Habiba Alaoui2, Houda Bachir2
1Internal Medicine, University Mohammed First - Faculté of Medicine and Pharmacy, Oujda, MAR.
Cureus
|April 14, 2022
Summary
Primary orbital lymphoma, a rare B cell malignancy, can mimic inflammatory conditions. Early diagnosis and treatment with chemotherapy and immunotherapy led to complete remission in a challenging case.
Area of Science:
- Oncology
- Ophthalmology
- Hematology
Background:
- Non-Hodgkin lymphomas, predominantly B cell types, are increasing globally.
- Primary orbital lymphoma is a rare diagnosis that can be mistaken for inflammatory orbitopathy.
Observation:
- A 52-year-old male presented with a five-year history of presumed inflammatory orbitopathy.
- Worsening symptoms and exophthalmia prompted further investigation.
Findings:
- The patient was diagnosed with a primary orbital lymphoma of the marginal zone type.
- Treatment with RCHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy plus immunotherapy resulted in complete lesion disappearance.
Implications:
- This case highlights the importance of considering rare diagnoses like orbital lymphoma in persistent or worsening orbitopathies.
- Prompt diagnosis and appropriate treatment, including chemotherapy and immunotherapy, are crucial for favorable outcomes in primary orbital lymphoma.
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