Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

38.6K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biomaterial-Integrated Electroporation for Therapeutic Delivery: From Gene Editing to Tumor Ablation and Immune Modulation.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Closed-loop iron chelate recycling via molecularly imprinted hydrogels suppresses ferroptosis.

Nature communications·2026
Same author

Targeting RBPMS selectively eliminates FOXO1-mediated stem cell signatures in mouse models of acute myeloid leukemia.

Science translational medicine·2026
Same author

In Situ Stress-Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Lactate metabolism reprogramming through orthogonal tandem catalysis to reverse intervertebral disc degeneration.

Nature communications·2026
Same author

Neuroregulatory Biomaterials for Intervertebral Disc Regeneration via Neuro-Disc Microenvironment Modulation.

Research (Washington, D.C.)·2026

Related Experiment Video

Updated: Sep 27, 2025

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
11:20

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

7.7K

Dual Biosignal-Functional Injectable Microspheres for Remodeling Osteogenic Microenvironment.

Yang Sun1, Qianrong Zhou1, Yawei Du2

  • 1Department of Stomatology, Zhongshan hospital, Fudan University, No. 180 Fenglin road, Shanghai, 200032, China.

Small (Weinheim an Der Bergstrasse, Germany)
|April 14, 2022
PubMed
Summary

Engineered microspheres accelerate bone repair by reprogramming macrophages using physical and molecular signals. This dual-action approach enhances M2 macrophage polarization for improved bone regeneration.

Keywords:
IL-4/Ls/PLLA microspheresdual signalsmicroenvironmentosteogenesisregenerative medicine

More Related Videos

Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
10:32

Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Published on: May 19, 2023

2.7K
A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
08:28

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

6.8K

Related Experiment Videos

Last Updated: Sep 27, 2025

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
11:20

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

Published on: March 29, 2018

7.7K
Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
10:32

Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Published on: May 19, 2023

2.7K
A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
08:28

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

6.8K

Area of Science:

  • Biomaterials Science
  • Immunology
  • Regenerative Medicine

Background:

  • Bone defect regeneration relies on M2 macrophages, influenced by physical and molecular cues.
  • Current strategies for bone repair need to better control macrophage behavior.

Purpose of the Study:

  • To develop immunoengineered porous microspheres for accelerated bone repair.
  • To investigate the dual regulation of physical and molecular signals for macrophage reprogramming.

Main Methods:

  • Fabrication of injectable poly(l-lactic acid) (PLLA) microspheres using microfluidics.
  • Modification of PLLA microspheres with interleukin-4 (IL-4)-loaded liposomes (Ls) to create IL-4/Ls/PLLA microspheres.
  • In vitro coculture assays with macrophages and osteoblasts, and in vivo studies in calvaria and maxillary sinus defect models.

Main Results:

  • IL-4/Ls/PLLA microspheres induced M2 macrophage polarization.
  • Enhanced osteoblast proliferation and differentiation in vitro.
  • Promoted bone defect regeneration in vivo by converting M1 to M2 macrophages.

Conclusions:

  • Dual biosignal-functional regulation by IL-4/Ls/PLLA microspheres precisely reprograms macrophages.
  • This immunoengineering strategy shows promise for clinical bone defect treatment.