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Updated: Sep 27, 2025

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
Published on: August 12, 2019
[A 51-year-old man with primary progressive aphasia]
Abstract:
Primary progressive aphasia (PPA) is a form of dementia in which brain circuits responsible for language and speech show progressive impairments. Based on consensus criteria PPA is divided into 3 main variants: a nonfluent/agrammatic, a semantic and a logopenic variant. Each variant has specific clinical characteristics, including neuropsychiatric symptoms, and is associated with different neuropathological findings. We describe a 51-year-old man with neuropsychiatric symptoms and progressive language disturbances. The diagnosis PPA was established after an extensive work-up in a psychiatric clinic. We describe which factors contributed to this complex diagnostic process and discuss why knowledge of this disorder is relevant for psychiatrists.
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