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Peptide Bonds

Peptide Bonds

A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...

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Updated: Sep 27, 2025

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Designer peptides as versatile building blocks for functional materials.

Sameer Dhawan¹, Hanuman Singh¹, Souvik Dutta¹

¹Department of Chemistry, Indian Institute of Technology Delhi, New Delhi 110016, India.

Bioorganic & Medicinal Chemistry Letters

|April 14, 2022

Summary

This summary is machine-generated.

Self-assembling peptides and pseudopeptides form diverse nanostructures for applications in drug delivery, biosensing, and nano-electronics. Understanding their collective molecular behavior is key to designing advanced functional materials.

Keywords:

Fibers Mechanism of self-assembly Nanotubes Peptides Pseudopeptides Self-assembly Vesicles

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Area of Science:

Materials Science
Biochemistry
Nanotechnology

Background:

Peptides and pseudopeptides self-assemble into various nanostructures like fibers, nanotubes, and vesicles.
The molecular mechanisms governing these self-assembly processes are not fully understood.
These nanostructures have broad applications in drug delivery, gene delivery, biosensing, bioimaging, catalysis, tissue engineering, and nano-electronics.

Purpose of the Study:

To present selected examples of self-assembling peptides and pseudopeptides.
To highlight the significance of self-assembly as a strategy for generating functional materials.
To underscore the advancements in designer synthetic self-assembling systems.

Main Methods:

Review of existing literature on self-assembling peptides and pseudopeptides.
Selection and presentation of diverse examples of self-assembling systems.
Discussion of the structural diversity and potential applications.

Main Results:

Demonstration of various self-assembled nanostructures formed by peptides and pseudopeptides.
Highlighting the range of applications for these nanostructured materials.
Showcasing the development of new synthetic self-assembling peptide systems.

Conclusions:

Self-assembly is a powerful and efficient method for creating complex functional nanomaterials.
Continued research into self-assembling peptides and pseudopeptides promises further innovation in nanotechnology and biomedicine.
Understanding molecular-level assembly is crucial for optimizing material properties and applications.