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Published on: January 13, 2017
Antibiotic natural product hunanamycin A: Lead identification towards anti-Salmonella agents
Rahul D Shingare1, John B MacMillan2, D Srinivasa Reddy3
1CSIR-National Chemical Laboratory, Division of Organic Chemistry, Dr. HomiBhabha Road, Pune, 411008, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, 110 025, India.
Abstract:
Design and synthesis of library of compounds around the antibiotic natural product hunanamycin A scaffold and their biological evaluation are disclosed here. These efforts resulted in identification of a lead compound 36, which is a structurally simplified analogue of original hunanamycin A with impressive activity against Salmonella enterica and possesses other druggable properties. In addition, no acute oral toxicity was observed for compound 36 in Swiss albino mice dosed up to 2 g/kg. It has the potential to be developed for the treatment of food infections caused by Salmonella.
