Diet-gut microbiota interactions on cardiovascular disease

Area of Science:

• Microbiology
• Cardiology
• Nutrition Science

Background:

• Cardiovascular diseases (CVD) are a leading global cause of death.
• The gut microbiota, a complex ecosystem, significantly influences host metabolism and disease.
• Dietary factors are key modulators of the gut microbiota and its role in CVD.

Purpose of the Study:

• To review the interplay between dietary modulation of the gut microbiota and CVD.
• To elucidate the mechanisms underlying diet-microbiota crosstalk in CVD progression.
• To explore dietary interventions targeting the gut microbiota for CVD management.

Main Methods:

• Literature review of studies on diet, gut microbiota, and cardiovascular diseases.
• Analysis of mechanisms linking gut microbiota, diet, and CVD pathogenesis.
• Discussion of microbial metabolites (TMAO, BAs, SCFAs, AAAs) in CVD.

Main Results:

• Dietary nutrients profoundly impact gut microbial communities.
• Gut microbiota dysbiosis contributes to CVD through mechanisms like inflammation and lipid metabolism dysfunction.
• Microbial metabolites such as TMAO, BAs, SCFAs, and AAAs play critical roles in CVD.

Conclusions:

• Diet-gut microbiota interactions are crucial in CVD development and progression.
• Targeting the gut microbiota through dietary interventions presents promising strategies for CVD prevention and treatment.