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Updated: Sep 27, 2025
Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
Published on: September 10, 2013
Design, synthesis and application in biological imaging of a novel red fluorescent dye based on a rhodanine
Zijing Li1, Bin Huang2, Yuan Wang3
1Key Laboratory of Flexible Electronics, Institute of Advanced Materials, Nanjing Tech University Nanjing P. R. China iamyttao@njtech.edu.cn.
Abstract:
A novel acceptor-donor-acceptor type molecule, namely 2-triphenylamine-1,3-dia[2-(3-ethyl-4-oxo-thiazolidin-2-ylidene)-malononitrile] (2RDNTPA), is designed and synthesized. 2RDNTPA exhibits a large Stokes shift of 244 nm and red fluorescence emission of 629 nm with a decent photoluminescence quantum yield of 13%. Furthermore, as a potential red fluorescent dye, 2RDNTPA can be applied in fluorescence imaging of living cancer cells (HepG2) with negligible cytotoxicity and a half maximal inhibitory concentration much more than 100 μM.
