Microfluidics for core-shell drug carrier particles - a review

Area of Science:

• Materials Science
• Nanotechnology
• Pharmaceutical Sciences

Background:

• Core-shell particles combine properties of their components for enhanced functionality.
• These particles are designed for targeted drug delivery, aiming to reduce side effects.
• Traditional fabrication methods have limitations in control and efficiency.

Purpose of the Study:

• To review microfluidic techniques for generating core-shell drug-carrier particles.
• To highlight the advantages of microfluidics over conventional methods.
• To provide an overview of microfluidic device designs for particle fabrication.

Main Methods:

• Review of fluidic concepts for micro/nanoparticle generation.
• Analysis of traditional and modern microfluidic device designs.
• Discussion of core-shell particle fabrication using microfluidics.

Main Results:

• Microfluidics allows for precise control over particle size and shape (nano- to micrometer levels).
• Fabrication using microfluidic chips is cost-effective, reproducible, and highly efficient.
• Integration capabilities of microfluidic systems offer significant advantages.

Conclusions:

• Microfluidic technology presents a promising approach for producing advanced core-shell drug carriers.
• The technique facilitates controlled drug release and improved therapeutic outcomes.
• Microfluidics offers superior performance and scalability for drug delivery systems.