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Updated: Sep 27, 2025

Expression and Purification of Nuclease-Free Oxygen Scavenger Protocatechuate 3,4-Dioxygenase
Published on: November 8, 2019
Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion
Meina Liu1,2, Esma Ucar3, Ziang Liu1,2
1State Key Laboratory of Fine Chemicals, Dalian University of Technology 2 Linggong Road 116024 Dalian China leiwang@dlut.edu.cn eua@dlut.edu.cn.
Abstract:
Singlet oxygen generated by photosensitization has limited potential in vivo due to light attenuation in tissues. However, controlled chemical generation of this reactive oxygen species is likely to open new therapeutic spaces to explore. The fact that its activity is limited by the rate of cycloreversion reaction and the diffusion distance of the excited state molecular oxygen species, is a clear advantage, considering the serious side effects of off-target anticoagulants. In this work, we present novel 1,4-naphthalene endoperoxides as potential anti-coagulant agents due to thermal release of singlet oxygen.
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