The concise synthesis and resolution of planar chiral [2.2]paracyclophane oxazolines by C-H activation
Shashank Tewari1, Maulik N Mungalpara1, Suraj Patel1
1School of Natural Sciences, Massey University Private Bag 11 222 Palmerston North 4442 New Zealand g.j.rowlands@massey.ac.nz.
Abstract:
Planar chiral [2.2]paracyclophanes are resolved through the direct C-H arylation of enantiopure oxazolines, providing a convenient route to ligands and chiral materials. Preliminary results show that hydrolysis followed by decarboxylative phosphorylation leads to enantiopure [2.2]paracyclophane derivatives that are otherwise challenging to prepare.
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