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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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Complete Resolution of Skull Base Solitary Plasmacytoma Using Proton-Beam Radiotherapy: A Case Report.

Hamza Khilji¹, Caroline Silver², Doaa Morrar³

¹Neurosurgery, Lenox Hill Hospital/Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, USA.

|April 15, 2022

Summary

A rare skull base plasmacytoma in a 36-year-old woman resolved completely with proton-beam radiation monotherapy. This case highlights the effectiveness of this treatment for solitary cranial lesions.

Keywords:

brain tumor chemotherapy multiple myeloma proton radiation radiotherapy skull base

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Last Updated: Sep 27, 2025

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Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

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Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

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Published on: July 5, 2021

Area of Science:

Neuro-oncology
Radiation Oncology
Pathology

Background:

Solitary plasmacytomas of the skull are infrequent, with base of skull involvement being particularly rare.
Accurate diagnosis and staging are crucial for effective management of these uncommon neoplasms.

Observation:

A 36-year-old woman presented with dizziness and headaches, indicative of a posterior cranial fossa lesion.
Radiographic and laboratory evaluations confirmed a solitary skull base lesion without evidence of systemic disease.

Findings:

Histopathological examination of the biopsy confirmed the lesion as a plasmacytoma.
The patient received proton-beam radiation therapy as a single modality treatment.
Complete clinical and radiographic resolution of the plasmacytoma was achieved post-treatment.

Implications:

This case demonstrates the potential of proton-beam radiation therapy as an effective monotherapy for solitary skull base plasmacytomas.
The findings suggest proton-beam radiation may offer a valuable, non-invasive treatment option for select patients with this rare condition.