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Updated: Sep 27, 2025
A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
Published on: March 3, 2023
[Research progress of antibacterial modification of orthopaedic implants surface]
Chaoqun Zhang1, Yipeng Wu2, Yongqing Xu2
1Graduate School of Kunming Medical University, Kunming Yunnan, 650000, P. R. China.
Objective:
To summarize the related research progress of antibacterial modification of orthopaedic implants surface in recent years.
Methods:
The domestic and foreign related literature in recent years was extensively consulted, the research progress on antibacterial modification of orthopaedic implants surface was discussed from two aspects of characteristics of infection in orthopedic implants and surface anti-infection modification.
Results:
The orthopaedic implants infections are mainly related to aspects of bacterial adhesion, decreased host immunity, and surface biofilm formation. At present, the main antimicrobial coating methods of orthopaedic implants are antibacterial adhesion coating, antibiotic coating, inorganic antimicrobial coating, composite antimicrobial coating, nitric oxide coating, immunomodulation, three-dimensional printing, polymer antimicrobial coating, and "smart" coating.
Conclusion:
The above-mentioned antibacterial coating methods of orthopedic implants can not only inhibit bacterial adhesion, but also solve the problems of low immunity and biofilm formation. However, its mechanism of action and modification are still controversial and require further research.
