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Related Experiment Videos

Neural cell adhesion molecule expression in Xenopus embryos.

K Balak, M Jacobson, J Sunshine

    Developmental Biology
    |February 1, 1987
    PubMed
    Summary

    Neural cell adhesion molecule (NCAM) expression in Xenopus embryos marks key developmental stages, including neural tube formation and nerve fiber tract development. This study maps NCAM

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    Area of Science:

    • Developmental biology
    • Neuroscience
    • Cell adhesion molecules

    Background:

    • Neural cell adhesion molecule (NCAM) is crucial for nervous system development.
    • Understanding NCAM's spatiotemporal expression is key to deciphering neural morphogenesis.

    Purpose of the Study:

    • To map the expression pattern of NCAM during early Xenopus development.
    • To correlate NCAM expression with specific developmental events like neural tube formation and neurite outgrowth.

    Main Methods:

    • Immunohistochemistry using a polyclonal antibody against Xenopus NCAM.
    • Analysis of NCAM expression from blastula to early swimming stages in Xenopus embryos.

    Main Results:

    • NCAM expression begins at the neural plate stage.
    • NCAM is detected in neural ectoderm, mesoderm, and chordamesodermal tissues.
    • Expression is observed in neural crest cells, developing nerve fiber tracts, and neuromuscular junctions.

    Conclusions:

    • NCAM is expressed post-neural induction and plays a role in neural plate and tube morphogenesis.
    • NCAM is involved in the development of neural crest derivatives and peripheral nervous system connections.
    • The study highlights NCAM's function in forming central and peripheral nerve pathways and neuromuscular junctions.

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