Related Experiment Video

Updated: Sep 26, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

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Hormone Treatment of Prostate Cancer:: Evidence for Usage and Safety

Muhieddine Labban1, Marwan Alkassis2, Khalid Alkhatib3

  • 1Division of Urological Surgery, Brigham and Women's Hospital, 45 Francis Street, Boston, MA 02115, USA. Electronic address: https://twitter.com/mdlabban.

The Urologic Clinics of North America
|April 16, 2022
PubMed

Insights

Androgen deprivation therapy (ADT) targets androgen activity in prostate cancer by acting on the pituitary, adrenal glands, or prostate cells. Careful consideration of ADT

Area of Science:

  • Oncology
  • Endocrinology

Background:

  • Androgen deprivation therapy (ADT) is a cornerstone in managing prostate cancer.
  • ADT functions by inhibiting androgen synthesis or action at various physiological levels.

Purpose of the Study:

  • To elucidate the mechanisms and clinical considerations of androgen deprivation therapy.
  • To highlight the importance of tailoring ADT based on disease characteristics.

Main Methods:

  • Review of androgenesis pathways.
  • Analysis of therapeutic targets within the endocrine system.
  • Evaluation of clinical application based on disease stage and resistance.

Main Results:

  • ADT inhibits androgen activity upstream (pituitary) or downstream (adrenal, prostate).
  • Therapeutic utilization is contingent upon disease stage, aggressiveness, and resistance patterns.

Conclusions:

  • Androgen deprivation therapy is a versatile treatment modality for prostate cancer.
  • Patient quality of life and management of comorbidities necessitate careful ADT side effect evaluation.
Keywords:
Androgen antagonistsAndrogen deprivation therapyHormonal adverse effectsHormone treatmentProstatic neoplasm

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