Current Research Trends in Cytokine Storm: A Scientometric Study.

Area of Science:

• Immunology
• Pathology
• Medical Research

Background:

• Coronavirus disease 2019 (COVID-19) is a global pandemic associated with high cytokine and chemokine levels, leading to cytokine storm syndrome.
• Cytokine storms represent severe inflammatory immune responses, highlighting immune dysregulation and the need for effective host defense.
• Understanding cytokine storms is crucial for managing severe inflammatory conditions.

Purpose of the Study:

• To conduct a scientometric analysis of research on cytokine storms over recent decades.
• To track emerging trends and summarize the pathogenesis and treatment of cytokine storm-associated diseases.
• To provide a comprehensive overview for researchers in the field.

Main Methods:

• Scientometric analysis of relevant literature.
• Review and synthesis of research on cytokine storm pathogenesis and treatment.
• Mapping of field distribution, knowledge structure, and research topic evolution.

Main Results:

• Identified key research areas, knowledge structure, and evolution of topics related to cytokine storms.
• Illustrated the occurrence, development, and treatment strategies for cytokine storm-related diseases.
• Revealed the multidisciplinary nature of cytokine storms.

Conclusions:

• Cytokine storms have diverse etiologies, including pathogens, iatrogenic factors, autoimmune, and monogenic diseases.
• The complexity of cytokine storms necessitates a multidisciplinary approach to understanding their pathophysiology, clinical presentation, and management.
• This scientometric study offers a macroscopic view and future research directions for cytokine storm investigation.