Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Other Disorders of Digestive System01:30

Other Disorders of Digestive System

1.1K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.1K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

72
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
72
Autoimmune Disorders01:29

Autoimmune Disorders

705
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
705
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

549
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
549
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

439
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
439

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Do Respiratory Viruses Cause Leaky Gut Syndrome?

Turkish archives of pediatrics·2026
Same author

A magnet cluster in the duodenum.

Journal of pediatric gastroenterology and nutrition·2025
Same author

Use of a specialized peptide-based enteral formula containing medium-chain triglycerides for enteral tube feeding in children with cerebral palsy and previous tube feeding intolerance on standard enteral formula: a prospective observational TolerUP study.

Frontiers in pediatrics·2025
Same author

The frequency of Duchenne muscular dystrophy/Becker muscular dystrophy and Pompe disease in children with isolated transaminase elevation: results from the observational VICTORIA study.

Frontiers in pediatrics·2023
Same author

Management of Gastrointestinal Foreign Bodies with Brief Review of the Guidelines.

Pediatric gastroenterology, hepatology & nutrition·2023
Same author

A Comparison Between Rome III and Rome IV Criteria in Children with Chronic Abdominal Pain: A Prospective Observational Cohort Study.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology·2022

Related Experiment Video

Updated: Sep 26, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

24.6K

Possible relationship between refractory celiac disease and malignancies.

Kaan Demiroren1

  • 1Department of Pediatric Gastroenterology, University of Health Sciences, Yuksek Ihtisas Teaching Hospital, Bursa 16000, Turkey. kaandemiroren@yahoo.com.

World Journal of Clinical Oncology
|April 18, 2022
PubMed
Summary

Celiac disease (CeD) can lead to refractory CeD, a condition where symptoms persist despite a gluten-free diet. Refractory CeD may progress to pre-lymphoma and enteropathy-associated T-cell lymphoma, highlighting the link between CeD and malignancies.

Keywords:
Enteropathy-associated T-cell lymphomaLow grade lymphomaPre-lymphomaRefractory celiac disease

More Related Videos

A Co-culture Method to Investigate the Crosstalk Between X-ray Irradiated Caco-2 Cells and PBMC
11:40

A Co-culture Method to Investigate the Crosstalk Between X-ray Irradiated Caco-2 Cells and PBMC

Published on: January 30, 2018

13.2K
A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
09:56

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

Published on: February 21, 2025

827

Related Experiment Videos

Last Updated: Sep 26, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

24.6K
A Co-culture Method to Investigate the Crosstalk Between X-ray Irradiated Caco-2 Cells and PBMC
11:40

A Co-culture Method to Investigate the Crosstalk Between X-ray Irradiated Caco-2 Cells and PBMC

Published on: January 30, 2018

13.2K
A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
09:56

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

Published on: February 21, 2025

827

Area of Science:

  • Gastroenterology
  • Immunology
  • Oncology

Background:

  • Celiac disease (CeD) is an autoimmune disorder triggered by gluten in genetically predisposed individuals.
  • CeD is characterized by specific antibodies, HLA-DQ2/DQ8, enteropathy, and multi-organ clinical manifestations.
  • Refractory CeD (rCeD) is diagnosed when CeD patients remain symptomatic despite a strict gluten-free diet for over 12 months with severe villous atrophy.

Purpose of the Study:

  • To review current literature and guidelines on the association between Celiac Disease and malignancies.
  • To explore the progression of refractory CeD to pre-lymphoma and enteropathy-associated T-cell lymphoma (EATL).

Main Methods:

  • Literature review of current research and clinical guidelines.
  • Analysis of the progression pathways from CeD to rCeD and subsequent lymphomagenesis.

Main Results:

  • Refractory CeD represents a significant risk factor for developing intestinal lymphoma.
  • A subset of refractory CeD cases exhibits abnormal monoclonal intraepithelial lymphocytes, indicating a pre-lymphomatous state.
  • Enteropathy-associated T-cell lymphoma (EATL) is a potential outcome following refractory CeD.

Conclusions:

  • Celiac disease carries an increased risk of malignancy, particularly intestinal lymphoma.
  • Early recognition and management of refractory CeD are crucial to potentially mitigate the risk of progression to lymphoma.
  • Further research is warranted to understand the mechanisms and improve outcomes for CeD patients at risk of malignancies.