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Related Experiment Video

Updated: Sep 26, 2025

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
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Interleukin-35 in autoimmune dermatoses: Current concepts.

Yuming Xie1, Huilin Zhang2, Junke Huang1

  • 1Department of Dermatology, The Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan 410011, China.

Open Medicine (Warsaw, Poland)
|April 18, 2022
PubMed
Summary

Interleukin-35 (IL-35), an immunosuppressive cytokine, plays a key role in autoimmune skin diseases like lupus and psoriasis. Targeting IL-35 may offer new therapeutic strategies for these conditions.

Keywords:
dermatomyositisinterleukin-35psoriasissystemic lupus erythematosussystemic sclerosis

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Area of Science:

  • Immunology
  • Dermatology
  • Cytokine Biology

Background:

  • Interleukin-35 (IL-35) is a recently identified cytokine within the IL-12 family.
  • IL-35 comprises p35 and Epstein-Barr virus-induced gene 3 subunits, mediating signal transduction via receptor binding.
  • It modulates immune cell functions, including T cells, B cells, and macrophages.

Purpose of the Study:

  • To elucidate the structure and biological characteristics of IL-35.
  • To summarize the role of IL-35 in the pathogenesis of autoimmune dermatoses.
  • To explore IL-35 as a potential therapeutic target for autoimmune skin diseases.

Main Methods:

  • Literature review and synthesis of existing research on IL-35.
  • Analysis of IL-35's immunomodulatory effects.
  • Correlation of IL-35's function with autoimmune dermatoses development.

Main Results:

  • IL-35 exhibits immunosuppressive properties.
  • IL-35 is implicated in the development of autoimmune dermatoses such as systemic lupus erythematosus, psoriasis, systemic sclerosis, and dermatomyositis.
  • Evidence suggests a significant role for IL-35 in immune dysregulation within these conditions.

Conclusions:

  • IL-35 is a crucial cytokine with immunosuppressive functions.
  • IL-35 is integral to the pathogenesis of several autoimmune dermatoses.
  • IL-35 represents a promising therapeutic target for treating autoimmune skin diseases.