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Related Experiment Video

Updated: Sep 26, 2025

Mindfulness in Motion MIM: An Onsite Mindfulness Based Intervention MBI for Chronically High Stress Work Environments to Increase Resiliency and Work Engagement
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Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in

Leina S Alrabadi1, Anne Dutton2, Anahita Rabiee3

  • 1Department of Pediatrics, Section of Pediatric Gastroenterology, Hepatology & Nutrition, Stanford University School of Medicine, Palo Alto, CA, USA.

JHEP Reports : Innovation in Hepatology
|April 18, 2022
PubMed
Summary
This summary is machine-generated.

Mindfulness-Based Stress Reduction (MBSR) improved stress and self-control in autoimmune hepatitis (AIH) patients. The intervention also reduced liver inflammation markers and steroid needs, suggesting stress management benefits AIH.

Keywords:
AIH, autoimmune hepatitisALT, alanine aminotransferaseAutoimmune hepatitisBSCS, brief self-control scaleCytokinesMBSRMBSR, mindfulness-based stress reductionMIF, macrophage migratory inhibitor factorPSS, perceived stress scalePsychological stressREDCap, research electronic data captureSRRS, social readjustment rating scaleStress reductionULN, upper limits of normal

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Area of Science:

  • Hepatology
  • Immunology
  • Psychiatry

Background:

  • Psychological stress can worsen autoimmune hepatitis (AIH) disease activity and increase relapse risk.
  • Mindfulness-Based Stress Reduction (MBSR) is a proven technique for managing stress and improving emotional regulation.

Purpose of the Study:

  • To assess the impact of an 8-week MBSR program on quality of life, disease activity, and cytokine profiles in adult AIH patients.
  • To explore MBSR as a potential intervention for managing stress and improving outcomes in AIH.

Main Methods:

  • A single-arm pilot study involving adult AIH patients undergoing an 8-week MBSR program.
  • Evaluated perceived stress (PSS), self-control (BSCS), serum ALT levels, cytokine profiles, and medication dosages before and after the intervention.

Main Results:

  • 71% of patients showed significant improvement in perceived stress and self-control scores post-MBSR, sustained at 12 months.
  • A trend towards reduced ALT levels was observed, alongside significant reductions in prednisone dosage, which persisted at 12 months.
  • Significant improvements were noted in key inflammatory cytokine levels (IL-6, IL-8, IL-10, IL-17, IL-23, and sCD74/MIF ratio) post-MBSR.

Conclusions:

  • MBSR significantly improved psychological well-being and reduced inflammatory markers in AIH patients.
  • Stress modification through MBSR may positively influence disease activity and reduce medication requirements in AIH.
  • Further research is warranted to establish MBSR as a complementary therapy for autoimmune hepatitis.