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Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation

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Moisturizing effectiveness of immediate compared with delayed moisturization.

Kim Han Nguyen^1,2, Le Duy Pham¹, Thi Thu Thao Nguyen³

¹Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.

Journal of Cosmetic Dermatology

|April 18, 2022

Summary

This summary is machine-generated.

Immediate or delayed application of moisturizers after bathing yields similar skin hydration benefits. This study found no significant difference in stratum corneum hydration (SCH) or transepidermal water loss (TEWL) reduction between immediate and delayed application.

Keywords:

SCH TEWL bathing moisturizing skin barrier

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Area of Science:

Dermatology
Skin Barrier Function
Cosmetic Science

Background:

Moisturizers are crucial for skin barrier integrity, impacting stratum corneum hydration (SCH) and transepidermal water loss (TEWL).
Current guidelines recommend immediate post-bathing application of moisturizers, but supporting evidence is limited.

Purpose of the Study:

To evaluate the effectiveness of immediate versus delayed (30 minutes) moisturizer application on SCH and TEWL.
To investigate the impact of timing on moisturizer efficacy in healthy individuals.

Main Methods:

A crossover study involving 60 healthy Vietnamese volunteers (18-25 years).
Measurements of SCH and TEWL were taken on non-moisturized, immediately moisturized, and 30-minute delayed moisturized skin areas.

Main Results:

Moisturizer application significantly increased SCH and decreased TEWL compared to non-moisturized skin.
No significant difference was observed in the percentage changes of SCH and TEWL between immediate and delayed moisturizing.
Both immediate and delayed application demonstrated significant improvements in skin hydration and barrier function.

Conclusions:

The tested moisturizer effectively improved SCH and reduced TEWL.
The timing of moisturizer application (immediate vs. delayed) did not influence its effectiveness on healthy skin.
Current recommendations for immediate post-bathing application may need reconsideration pending further research.