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Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...

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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

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Published on: February 8, 2018

PD-L1 expression in invasive solid papillary breast carcinomas.

Sevdegul Aydın Mungan¹, Zeynep Sagnak Yılmaz², Ismail Saygın¹

¹Department of Pathology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey.

Indian Journal of Pathology & Microbiology

|April 18, 2022

Summary

This summary is machine-generated.

Programmed cell death ligand-1 (PD-L1) expression in rare invasive solid papillary carcinomas correlates with molecular subtypes and Ki-67 index. Both tumor cell and immune cell PD-L1 expression can predict immunotherapy response in these breast tumors.

Keywords:

Breast carcinoma immunohistochemistry programmed cell death ligand-1 solid papillary carcinoma

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Area of Science:

Oncology
Immunology
Pathology

Background:

Invasive solid papillary carcinoma (ISPC) is a rare breast tumor subtype.
Understanding its molecular characteristics is crucial for targeted therapies.

Purpose of the Study:

To investigate programmed cell death ligand-1 (PD-L1) expression in ISPC.
To correlate PD-L1 status with molecular subtypes and clinicopathological parameters.
To assess PD-L1's potential role in predicting immunotherapy response.

Main Methods:

Immunohistochemical analysis of 19 ISPC cases.
Molecular subtyping using ER/PR, Her-2/neu, and Ki-67.
Evaluation of PD-L1 expression on tumor and immune cells.

Main Results:

PD-L1 expression was found in 21% of ISPC cases.
A significant correlation was observed between PD-L1 expression and molecular subtypes (luminal B and A).
Higher Ki-67 index and PD-L1 expression on intratumoral lymphocytes were associated with PD-L1 positivity.

Conclusions:

PD-L1 expression in ISPC is linked to specific molecular subtypes and proliferation markers.
Both tumor cell and tumor-infiltrating lymphocyte PD-L1 expression may predict immunotherapy benefit.
Clinicopathological parameters, including molecular subtype and Ki-67, can guide immunotherapy decisions.