Metastatic Renal Cell Carcinoma With Sarcomatoid Features

Area of Science:

• Oncology
• Nephrology
• Pathology

Background:

• Renal cell carcinoma (RCC) is a significant health concern.
• Metastatic RCC with sarcomatoid features presents a challenging clinical scenario.
• Early and accurate diagnosis is crucial for effective treatment.

Purpose of the Study:

• To present a case of metastatic clear cell renal cell carcinoma (RCC) with sarcomatoid features.
• To highlight the diagnostic process and initial management of advanced RCC.
• To underscore the importance of histopathological analysis in risk stratification.

Main Methods:

• Clinical presentation of a 38-year-old female patient.
• Laboratory investigations including serum calcium and lactate dehydrogenase.
• Diagnostic imaging with CT scan.
• Histopathological analysis of a renal mass biopsy.

Main Results:

• Diagnosis of clear cell renal cell carcinoma (RCC) with 30% sarcomatoid features.
• Identification of a large left renal mass with lung and mediastinal lymph node metastases.
• Classification as International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) poor-risk metastatic RCC.
• Initiation of first-line systemic therapy.

Conclusions:

• Metastatic clear cell renal cell carcinoma (RCC) with sarcomatoid features requires prompt diagnosis and treatment.
• Multimodal diagnostic approaches are essential for staging and risk assessment.
• Systemic therapy is indicated for patients with poor-risk metastatic RCC.