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Prediction factors for the risk of diffuse non-toxic goiter development in type 2 diabetic patients
Volodymyr Musiienko1, Andriy Sverstiuk2, Andriy Lepyavko3
1Department of Functional and Laboratory Diagnostics, I Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.
Abstract:
Type 2 diabetes mellitus (T2DM) patient outcomes, treatment options, and corresponding healthcare expenses are affected by the presence of different comorbidities.
Aim:
The aim of this work was to develop an algorithm for predicting the risk of diffuse non-toxic goitre development in patients with T2DM according to a mathematical model obtained by regression analysis, for the timely implementation of appropriate preventive measures among T2DM patients.
Materials And Methods:
We analyzed 541 medical records of T2DM patients.
Results:
It was found the following risk factors influencing the occurrence of diffuse non-toxic goitre in patients with T2DM: age, gender, body mass index (BMI), glycosylated hemoglobin (HbA1c), homeostasis model assessment for insulin resistance (HOMA-IR), thyroid stimulating hormone (TSH), free thyroxine (fT4). Prognostic model of the risk of diffuse non-toxic goitre development in T2DM patients was built using multiple regression analysis. In order to stratify the risk of diffuse nontoxic goitre development in T2DM patients, the following criteria were proposed: no risk at RCG ≤ 5.0; low risk at 5.1≤ RCG ≤12,9; high risk at RCG ≥13.0.; where RCG - risk coefficient for the diffuse non-toxic goiter development in T2DM patients.
Conclusions:
Therefore, the developed algorithm and mathematical model for predicting the development of diffuse non-toxic goitre in T2DM patients are highly informative and allow to determine in advance the contingent of patients with a high probability of diffuse non-toxic goitre risk based both on routine laboratory data, such as HbA1c, HOMA-IR, TSH, fT4 levels and such factors as age, gender, and BMI.
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