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Updated: Sep 26, 2025

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

Published on: April 13, 2017

Microglia and Neurodevelopmental Disorders.

John R Lukens^1,2, Ukpong B Eyo^1,2

¹Department of Neuroscience, University of Virginia School of Medicine, Charlottesville, Virginia, USA;

Annual Review of Neuroscience

|April 18, 2022

Summary

This summary is machine-generated.

Microglia, the brain's immune cells, are crucial for neurodevelopment. Their dysfunction is linked to neurodevelopmental disorders (NDDs), with gut microbiome interactions emerging as a key factor in NDD progression.

Keywords:

Rett syndrome autism microbiome microglia neurodevelopmental disorders

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Last Updated: Sep 26, 2025

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Published on: April 13, 2017

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Characterization and Isolation of Mouse Primary Microglia by Density Gradient Centrifugation

Characterization and Isolation of Mouse Primary Microglia by Density Gradient Centrifugation

Published on: February 16, 2018

Area of Science:

Neuroscience
Immunology
Developmental Biology

Background:

Microglia are resident immune cells in the brain, essential for neurodevelopment.
Microglial dysfunction is increasingly implicated in the pathology of neurodevelopmental disorders (NDDs).

Purpose of the Study:

To review the mechanistic roles of microglia in brain development and neuronal circuit formation.
To examine the link between microglial dysregulation and autism spectrum disorder (ASD) pathogenesis.
To explore the influence of the gut microbiome on microglial biology and its impact on NDDs.

Main Methods:

Literature review of microglial function in neurodevelopment.
Analysis of studies linking microglial biology to NDDs, including ASD.
Synthesis of research on gut microbiome-microglia interactions in the context of NDDs.

Main Results:

Microglia actively sculpt the developing brain and neuronal circuits.
Evidence suggests microglial dysregulation is associated with ASD pathogenesis.
The gut microbiome significantly modulates microglial biology, influencing NDD progression.

Conclusions:

Microglia play indispensable roles in normal brain development.
Understanding microglial dysfunction is critical for NDD research.
The gut microbiome represents a novel therapeutic target for modulating microglial function in NDDs.