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Updated: Sep 26, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
Patient attendance at molecular tumor board: A new means of shared decision making?
Timothy Lewis Cannon1, Laura Knopp2, Hongkun Wang3
1Department of Oncology, Associate Professor University of Virginia, Inova Schar Cancer Institute, Fairfax, VA.
Abstract:
Patient engagement in medical decision-making improves patient related outcomes through compliance and patient satisfaction. The Inova Schar Cancer Institute has a weekly molecular tumor board (MTB) to match comprehensive genomic sequencing results with targeted therapies for patients. Primary oncologists extended MTB invitations to their patients. Ultimately, 20 of the 139 patients attended and completed pre- and post MTB surveys. There was a statistically significant change from the pre- to post- survey for the question "I am satisfied with how well informed I am about targeted therapy" with P = 0.016. Patients who attended MTB reported higher levels of satisfaction with their knowledge of targeted therapy after MTB as compared to before. A more holistic method of studying this practice would include sampling a larger patient population and a formal evaluation of the physicians' experience with patients attending.
Insights
Patient participation in medical decisions enhances outcomes. Attending a molecular tumor board (MTB) significantly improved patients' understanding and satisfaction with targeted therapy knowledge.
Area of Science:
- Oncology
- Genomics
- Patient Engagement
Background:
- Patient engagement in medical decision-making is crucial for improving outcomes like compliance and satisfaction.
- The Inova Schar Cancer Institute utilizes a weekly molecular tumor board (MTB) to align comprehensive genomic sequencing with targeted therapies.
- Oncologists invited patients to attend the MTB sessions.
Discussion:
- A study evaluated patient satisfaction with targeted therapy information before and after MTB attendance.
- A statistically significant improvement in patient satisfaction regarding their knowledge of targeted therapy was observed (P=0.016).
- Patients attending the MTB reported increased satisfaction with their understanding of targeted therapy.
Key Insights:
- Molecular tumor board attendance positively impacts patient satisfaction with knowledge of targeted therapies.
- Enhanced patient understanding of targeted therapy can lead to better engagement in treatment decisions.
- The MTB serves as a valuable platform for personalized cancer treatment discussions.
Outlook:
- Future research should involve larger patient populations to validate these findings.
- A formal evaluation of physician experiences with patient participation in the MTB is recommended.
- Exploring broader impacts of patient engagement in molecular tumor boards on treatment adherence and outcomes is warranted.
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