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Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
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Related Experiment Video

Updated: Sep 26, 2025

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

Organ-on-a-chip: current gaps and future directions.

Pelin L Candarlioglu¹, Gianni Dal Negro¹, David Hughes²

¹In Vitro/In Vivo Translation-Complex In Vitro Models, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Biochemical Society Transactions

|April 19, 2022

Summary

Organ on Chip (OoC) technology is gaining traction for its potential to improve drug development and reduce animal testing. This review highlights current advancements, challenges, and future directions for robust, human-relevant OoC tools.

Keywords:

drug discovery and design organ on chip translational science

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Last Updated: Sep 26, 2025

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Area of Science:

Biotechnology
Translational Science
Drug Discovery

Background:

Organ on Chip (OoC) technology has emerged as a significant area of interest in the past decade.
OoC offers potential for advancing both basic and translational scientific research.
The Biochemical Society is actively reviewing OoC technology to address its current state, challenges, and future trajectory.

Purpose of the Study:

To review the state-of-the-art in Organ on Chip (OoC) technology.
To identify bottlenecks and future directions for OoC development.
To discuss requirements for OoC technology to meet expectations in pharmaceutical applications and reduce reliance on animal models.

Main Methods:

A conference convened key stakeholders in the OoC field.
Discussions involved academics, end-users, regulators, and technology developers.
The focus was on identifying requirements, challenges, and gaps in OoC technology.

Main Results:

The conference facilitated a comprehensive discussion on OoC technology's potential and limitations.
Key challenges and gaps were identified for developing robust, human-relevant OoC tools.
The need for OoC to positively impact pharmaceutical decision-making was emphasized.

Conclusions:

Organ on Chip technology holds significant promise for revolutionizing pharmaceutical research.
Addressing current challenges is crucial for realizing the full potential of OoC.
OoC can lead to more predictive and ethical models, reducing the overreliance on animal testing.