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Published on: February 9, 2019
Ligand-mediated nanomedicines against breast cancer: a review
Guilherme F Picheth1,2, Fernando A de O Ganzella1, João Oc Filizzola1
1Department of Basic Pathology, Federal University of Paraná, Curitiba, Paraná, Brazil.
Abstract:
Ligand-mediated targeting represents the cutting edge in precision-guided therapy for several diseases. Surface engineering of nanomedicines with ligands exhibiting selective or tailored affinity for overexpressed biomolecules of a specific disease may increase therapeutic efficiency and reduce side effects and recurrence. This review focuses on newly developed approaches and strategies to improve treatment and overcome the mechanisms associated with breast cancer resistance.

