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Nx4 Modulated Resting-State Functional Connectivity Between Amygdala and Prefrontal Cortex in a Placebo-Controlled,

Tara Chand1,2, Sarah Alizadeh1,2, Meng Li2

  • 1Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.

Brain Connectivity
|April 19, 2022
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Summary
This summary is machine-generated.

Neurexan (Nx4) enhanced resting-state functional connectivity (rsFC) between the amygdala and prefrontal cortex in stressed individuals. This suggests Nx4 may improve emotion regulation and reduce stress susceptibility.

Keywords:
amygdalabrain networkscomplementary therapiesfMRIresting-state functional connectivity

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Resting-state functional connectivity (rsFC) is crucial for brain function and can be altered by stress.
  • The amygdala and prefrontal cortex are key regions involved in emotion regulation and stress response, with altered connectivity observed during stress.
  • Neurexan (Nx4), a multicomponent drug, has shown potential in reducing amygdala activation and stress symptoms.

Purpose of the Study:

  • To investigate the effect of Neurexan (Nx4) on the resting-state functional connectivity (rsFC) of the amygdala in mildly to moderately stressed participants.
  • To assess changes in rsFC before and after a single dose of Nx4 or placebo, prior to stress induction.

Main Methods:

  • A randomized, placebo-controlled, double-blind, crossover trial involving 39 participants.
  • Resting-state functional magnetic resonance imaging (rsFC) scans were acquired pre-dose and post-dose.
  • Global functional connectivity density (gFCD) analysis and seed-based rsFC analysis using the left centromedial amygdala (CeMA) as a seed.

Main Results:

  • Neurexan (Nx4) was found to reduce prefrontal cortex global functional connectivity density (gFCD).
  • Nx4 significantly enhanced negative connectivity between the left centromedial amygdala (CeMA) and the dorsolateral and medial prefrontal cortices.
  • These findings were observed in a resting-state condition before stress induction.

Conclusions:

  • Neurexan (Nx4) modulates resting-state functional connectivity, specifically strengthening the connection between the amygdala and prefrontal cortex.
  • This mechanism may indicate enhanced regulatory control of the amygdala at rest, potentially leading to reduced stress susceptibility.
  • Further research is warranted to confirm this effect and its clinical implications for stress management.