Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cellular immunity in Mooren's ulcer.

B J Mondino, S I Brown, B S Rabin

    American Journal of Ophthalmology
    |June 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Mooren's ulcer may be linked to cell-mediated immunity. Macrophage migration inhibition factor testing showed positive responses to corneal antigen in most patients with this eye condition.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Influences on life-span of NZB/W mice.

    Immunology today·2014
    Same author

    Effect of Cyclosporin-A on Hepatic and Renal Allograft Mononuclear Cell Infiltration.

    Transplantation proceedings·2010
    Same author

    Cluster of Mycobacterium chelonae keratitis cases following laser in-situ keratomileusis.

    American journal of ophthalmology·2001
    Same author

    Characterization of the central nervous system innervation of the rat spleen using viral transneuronal tracing.

    The Journal of comparative neurology·2001
    Same author

    Experimental staphylococcal endophthalmitis.

    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde·2001
    Same author

    Identification of delta- and mu-type opioid receptors on human and murine dendritic cells.

    Journal of neuroimmunology·2001
    Same journal

    Reply to Comment on Visual Field Progression in Glaucoma Patients with Delayed Follow-Up.

    American journal of ophthalmology·2026
    Same journal

    Comment on: "Safety and efficiency reducing retinopathy of prematurity guideline sensitivity: an external validation using a large US-based dataset".

    American journal of ophthalmology·2026
    Same journal

    Reply to Comment on "Clinicopathological and Imaging Distinction Between Ocular Adnexal MALT Lymphoma and IgG4-Related Ophthalmic Disease".

    American journal of ophthalmology·2026
    Same journal

    Comment on: Visual Field Progression in Glaucoma Patients With Delayed Follow-Up.

    American journal of ophthalmology·2026
    Same journal

    Corneal sensitivity changes and nerve plexus abnormalities in noninfectious anterior uveitis.

    American journal of ophthalmology·2026
    Same journal

    Role of Menopausal Hormone Therapy on Strabismus, Strabismus Surgery, and Reoperation Rates.

    American journal of ophthalmology·2026
    See all related articles

    Area of Science:

    • Ophthalmology
    • Immunology
    • Cellular Biology

    Background:

    • Mooren's ulcer is a rare, progressive ulcerative disease of the cornea.
    • The exact etiology of Mooren's ulcer remains incompletely understood, with theories suggesting autoimmune or infectious causes.

    Purpose of the Study:

    • To investigate the role of cellular immunity in the pathogenesis of Mooren's ulcer.
    • To assess the presence of cell-mediated immune responses to corneal antigens in patients diagnosed with Mooren's ulcer.

    Main Methods:

    • Macrophage migration inhibition factor (MIF) testing was performed on seven patients clinically diagnosed with Mooren's ulcer.
    • Testing involved assessing cellular immune response to corneal antigen.

    Main Results:

    Related Experiment Videos

    • Six out of seven patients with Mooren's ulcer exhibited positive macrophage migration inhibition in response to corneal antigen.
    • One patient showed a negative MIF response during disease inactivity, which converted to positive during a concurrent homograft rejection episode.

    Conclusions:

    • Cell-mediated immunity, specifically a response to corneal antigen, is suggested to play a significant role in the development of Mooren's ulcer.
    • MIF testing can serve as an indicator of cellular immune activity in Mooren's ulcer pathogenesis.