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Nerve transfer with 3D-printed branch nerve conduits.

Jing Zhang1, Jie Tao2, Hao Cheng2

  • 1Department of Neurosurgery, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, P.R. China.

Burns & Trauma
|April 20, 2022
PubMed
Summary

3D-printed branch nerve conduits enable successful nerve repair in rats, preserving donor nerve function. This innovative technique offers a promising solution for nerve transfer procedures.

Keywords:
3D printingBranch nerve conduitNerve regenerationNerve transfer

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Area of Science:

  • Biomaterials Engineering
  • Regenerative Medicine
  • Surgical Innovation

Background:

  • Nerve transfer is crucial for nerve repair but often causes donor nerve functional loss.
  • Current end-to-end nerve coaptation methods have limitations.
  • Developing strategies to mitigate donor nerve deficits is essential.

Purpose of the Study:

  • To evaluate the efficacy of 3D-printed branch nerve conduits for nerve transfer.
  • To assess functional recovery and histological outcomes in a rat model.
  • To determine if branch conduits can preserve donor nerve function.

Main Methods:

  • Customized, gelatine-methacryloyl-based branch conduits were fabricated using 3D printing.
  • Conduits were characterized through in vitro and in vivo assessments.
  • Nerve transfer efficacy was evaluated in rats via electrophysiology and histology.

Main Results:

  • A single nerve stump successfully formed a complex neural network within the 3D-printed multibranch conduit.
  • A two-branch conduit facilitated tibial nerve to peroneal nerve transfer in rats.
  • Successful nerve repair and functional recovery were observed in the peroneal nerve.

Conclusions:

  • 3D-printed two-branch conduits can repair the peroneal nerve while preserving partial function of the donor tibial nerve.
  • This technology presents a viable approach for nerve transfer, minimizing donor nerve morbidity.
  • 3D-printed branch nerve conduits offer a novel solution for reconstructive nerve surgery.