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Grading Anterior Chamber Inflammation with Anterior Segment Optical Coherence Tomography: An Overview
Morgan Maring1, Steven S Saraf2,3, Marian Blazes2
1Keck School of Medicine of University of Southern California, University of Southern California, Los Angeles, California, USA.
Ocular Immunology and Inflammation
|April 20, 2022
Summary
Objective grading of anterior chamber inflammation (ACI) is challenging. Modern anterior segment optical coherence tomography (OCT) with AI shows promise for more accurate and continuous ACI measurement in uveitis.
Area of Science:
- Ophthalmology
- Medical Imaging
Background:
- Objective grading of anterior chamber inflammation (ACI) in uveitis remains a clinical challenge.
- Current Standardization of Uveitis Nomenclature (SUN) criteria have limitations, including interobserver variability and discrete categorization.
Purpose of the Study:
- To explore the potential of anterior segment optical coherence tomography (AS-OCT) for objective and continuous grading of ACI.
- To identify barriers to the widespread adoption of AS-OCT for ACI assessment.
Main Methods:
- Review of existing literature on AS-OCT for ACI assessment.
- Discussion of technological advancements in OCT devices and artificial intelligence (AI).
Main Results:
- AS-OCT has shown correlation with clinical findings but faces barriers to standardization.
- Variability in OCT devices, protocols, quantification methods, and cell differentiation hinder widespread use.
Conclusions:
- Modern AS-OCT devices and AI techniques offer significant potential for improving ACI grading.
- Further standardization is needed to enhance the clinical applicability of AS-OCT for uveitis management.
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