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Updated: Sep 26, 2025

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
Rapidly developed heterotopic ossification: a rare complication after trauma
Jae H T Lee1, Janaka Balasooriya1, Thembekile Ncube1
1Department of General Surgery, The Canberra Hospital, Garran, Australian Capital Territory, Australia.
Heterotopic ossification (HO) is aberrant bone growth in tissues. This case study shows rapid HO after trauma and laparotomy complicated abdominal closure, necessitating multiple surgeries and prolonged recovery.
Area of Science:
- Trauma Surgery
- Surgical Complications
- Bone Biology
Background:
- Heterotopic ossification (HO) involves abnormal bone formation in non-skeletal tissues.
- Traumatic injuries and abdominal surgeries can precipitate HO.
- This case highlights a rare, aggressive presentation of HO.
Observation:
- A 44-year-old male sustained multi-organ injuries from a truck accident.
- He underwent damage control laparotomy and multiple subsequent procedures.
- Abdominal incision closure was repeatedly unsuccessful due to rigidity.
Findings:
- Computed tomography revealed advanced heterotopic ossification at the wound edge 20 days post-injury.
- The rapid progression of HO significantly impeded abdominal wall approximation.
- This suggests HO can be an early and challenging complication.
Implications:
- Early recognition of HO is crucial in trauma patients with abdominal injuries.
- Awareness of HO can guide surgical management and potentially improve outcomes.
- Further research into early HO detection and prevention post-trauma is warranted.
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