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A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
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A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

Published on: April 18, 2025

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Proteoform-Selective Imaging of Tissues Using Mass Spectrometry

Manxi Yang1, Hang Hu1, Pei Su1,2

  • 1Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.

Angewandte Chemie (International Ed. in English)
|April 21, 2022
PubMed
Summary

Nanospray desorption electrospray ionization mass spectrometry imaging (nano-DESI MSI) enables proteoform-specific tissue analysis. This new method reveals distinct protein variant patterns across different brain regions in rats.

Keywords:
Mass Spectrometry ImagingOn-Tissue Top-down ProteomicsPost-Translational ModificationsProteoforms

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