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Surface Modification of Lipid-Based Nanoparticles.

Yining Xu1, Thibaut Fourniols1, Yasmine Labrak1,2

  • 1Advanced Drug Delivery and Biomaterials, UCLouvain, Université Catholique de Louvain, Louvain Drug Research Institute, Avenue Mounier, 73 B1.73.12, 1200 Brussels, Belgium.

ACS Nano
|April 21, 2022
PubMed
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Surface modification of lipid nanoparticles enhances therapeutic delivery. This review covers grafting methods, characterization, and the impact of these modifications on overcoming biological barriers for future applications.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Drug Delivery

Background:

  • Lipid-based nanocarriers are increasingly utilized, notably in vaccine development (e.g., COVID-19 pandemic).
  • Surface modification of nanocarriers aims to improve therapeutic targeting and reduce off-site accumulation.
  • Significant research focuses on enhancing nanocarrier performance through surface functionalization.

Purpose of the Study:

  • To review methods for lipid nanoparticle grafting.
  • To discuss techniques for separating and characterizing grafted nanoparticles.
  • To critically assess the impact of surface modifications on overcoming biological barriers.

Main Methods:

  • Literature review of lipid nanoparticle grafting techniques.
  • Analysis of methods for purification and characterization of modified nanoparticles.
Keywords:
characterizationchemical reactiongraftingligandslipid nanoparticlesmucussurface modificationtargeting

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  • Evaluation of the efficacy of grafted nanocarriers in preclinical and clinical studies.

    • Main Results:

    • Overview of diverse lipid nanoparticle grafting strategies.
    • Identification of key separation and characterization techniques.
    • Critical assessment of the benefits and limitations of surface modifications.

    Conclusions:

    • Surface modification of lipid nanoparticles offers potential for improved drug and vaccine delivery.
    • Further research is needed to fully understand and optimize the impact of grafting on biological barrier penetration.
    • Future directions include advanced functionalization for targeted delivery and enhanced therapeutic outcomes.