Basosquamous Basal Cell Carcinoma with Bone Marrow Metastasis.

Area of Science:

• Oncology
• Dermatology

Background:

• Basal cell carcinoma (BCC) is the most common skin cancer in Caucasians, typically slow-growing with low metastatic potential.
• Untreated BCC can exhibit invasive growth patterns over time.

Observation:

• A patient presented with a primary BCC in the sub-mammary region, which had extensively metastasized to the skeleton and bone marrow.
• Post-surgery, the patient developed normocytic anemia and elevated inflammatory markers, with [18F]FDG PET/CT revealing widespread skeletal and bone marrow uptake.
• Biopsy confirmed BCC infiltration with identical histopathological features to the primary tumor.

Findings:

• The case demonstrates an unusual presentation of advanced BCC with widespread osseous metastases.
• Histopathology confirmed the metastatic nature of the tumor, consistent with the primary BCC.

Implications:

• Metastatic BCC carries a poor prognosis, underscoring the need for vigilant long-term patient monitoring.
• Identifying patients with risk factors for advanced BCC is essential for timely intervention and improved outcomes.