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3D Printing in Solid Dosage Forms and Organ-on-Chip Applications.

Tarek Kassem1, Tanoy Sarkar1, Trieu Nguyen1

  • 1Department of Pharmaceutical & Biomedical Sciences, College of Pharmacy, California Northstate University, Elk Grove, CA 95757, USA.

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|April 21, 2022
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Summary

3D printing (3DP) revolutionizes personalized medicine by enabling custom drug dosage forms and 3D models for drug screening and testing. This technology offers a comprehensive approach to pharmaceutical development and application.

Keywords:
3D printingCADadditive manufacturingbiosensingorgan-on-chippersonalized medicinespritam

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Area of Science:

  • Pharmaceutical Technology
  • Biomedical Engineering
  • Materials Science

Background:

  • 3D printing (3DP) has emerged as a transformative technology in pharmaceutics.
  • The recent approval of Spritam, a 3DP-produced pharmaceutical, highlights its growing significance.
  • Ongoing research addresses limitations like excipient choice, production time, and cost.

Purpose of the Study:

  • To provide a comprehensive overview of 3D printing processes in pharmaceutics.
  • To review different 3DP techniques, materials, and their respective advantages and disadvantages.
  • To explore the dual application of 3DP in creating personalized solid dosage forms and 3D models for drug evaluation.

Main Methods:

  • Review of current literature on 3D printing technologies in pharmaceutical applications.
  • Analysis of various 3D printing methods (e.g., inkjet printing, fused deposition modeling, stereolithography).
  • Evaluation of materials suitable for pharmaceutical 3D printing and their properties.

Main Results:

  • 3DP enables the creation of customized solid dosage forms for personalized medicine.
  • 3DP facilitates the development of 3D models for drug screening, sensing, and organ-on-chip applications.
  • The review details the pros and cons of different 3DP techniques and materials.

Conclusions:

  • 3D printing offers a versatile platform for both drug product manufacturing and preclinical drug evaluation.
  • The technology provides a complete application loop, from drug creation to its screening and testing.
  • Further advancements are expected to overcome current limitations and expand the scope of 3DP in pharmaceutics.