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[Progress in pulmonary enteric adenocarcinoma].

Y Zuo¹, H Bai¹, J M Ying²

¹Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology]

|April 21, 2022

Summary

This summary is machine-generated.

Pulmonary enteric adenocarcinoma (PEAC) is a rare lung cancer subtype mimicking colorectal cancer. Current research highlights its distinct molecular profile and clinical features, guiding treatment towards non-small cell lung cancer (NSCLC) therapies.

Keywords:

Clinical pathology Enteric adenocarcinoma Lung neoplasms Pathogenesis

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Area of Science:

Pulmonary Medicine
Oncology
Pathology

Background:

Pulmonary enteric adenocarcinoma (PEAC) is a rare histologic subtype of primary lung adenocarcinoma, characterized by an enteric component exceeding 50%.
PEAC shares morphological and immunohistochemical features with colorectal cancer, posing diagnostic challenges in differentiating it from lung metastatic colorectal cancer.
Potential origins include intestinal metaplasia of respiratory basal cells, possibly influenced by factors like smoking.

Purpose of the Study:

To summarize the key characteristics of pulmonary enteric adenocarcinoma.
To highlight diagnostic challenges and current understanding of its molecular and clinical features.
To inform treatment strategies and identify areas for future research.

Main Methods:

Review of existing literature on pulmonary enteric adenocarcinoma.
Analysis of reported immunohistochemical markers (CK7, CDX2, CK20, TTF1).
Compilation of clinical data including age, sex, smoking history, and lesion location.

Main Results:

KRAS mutations are frequently observed, while other driver mutations are rare.
Immunohistochemistry shows high positivity for CK7 (88.2%) and CDX2 (78.1%), with lower rates for CK20 (48.2%) and TTF1 (38.8%).
Clinical features include a mean onset age of 62 years, male predominance (56.5%), high smoking prevalence (78.8%), and frequent upper right lobe location (41.4%).

Conclusions:

Pulmonary enteric adenocarcinoma presents unique diagnostic and therapeutic considerations.
Current treatment recommendations align with non-small cell lung cancer (NSCLC) regimens.
Further research into molecular features, pathogenesis, and optimal therapies, including targeted and immunotherapy, is urgently needed.