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Updated: Sep 26, 2025
11:29
miRNA Expression Analyses in Prostate Cancer Clinical Tissues
Published on: September 8, 2015
10.9K
Microbiomes of Urine and the Prostate Are Linked to Human Prostate Cancer Risk Groups
Rachel Hurst1, Emma Meader2, Abraham Gihawi1
1Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK.
European Urology Oncology
|April 22, 2022
Summary
This study found specific anaerobic bacteria in urine and prostate samples are linked to higher prostate cancer risk and metastasis. These findings suggest the microbiome has prognostic potential for prostate cancer.
Area of Science:
- Microbiology
- Oncology
- Genomics
Background:
- Bacteria are implicated in various cancers, with prior links to prostate cancer.
- Understanding the prostate and urine microbiome is crucial for cancer research.
Purpose of the Study:
- To characterize the prostate and urine microbiome.
- To investigate the prognostic potential of bacteria in prostate cancer.
Main Methods:
- Analysis of urine sediment, extracellular vesicles, and cancer tissue microbiomes.
- Utilized 16S ribosomal amplicon sequencing, RNA-seq, and whole genome sequencing.
- Employed anaerobic culture and population-level 16S analysis.
Main Results:
- An association was found between urine bacteria and higher D'Amico risk prostate cancer.
- Four novel bacteria were identified in patient urine.
- Specific anaerobic genera, including novel isolates, correlated with cancer risk and metastasis development.
- A meta-analysis indicated a significant hazard ratio for disease progression associated with these bacteria.
Conclusions:
- The study characterizes the prostate and urine microbiomes.
- Specific anaerobic bacteria genera show prognostic potential for prostate cancer.
- The microbiome may serve as a prognostic tool in prostate cancer management.
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