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Cancer and obstructive sleep apnea: An updated meta-analysis
1Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Medicine
|April 22, 2022
Summary
Obstructive sleep apnea (OSA) is highly prevalent in cancer patients. This meta-analysis found that individuals with OSA have a significantly higher risk of developing cancer, with incidence linked to OSA severity.
Area of Science:
- Oncology
- Sleep Medicine
- Epidemiology
Background:
- The link between obstructive sleep apnea (OSA) and cancer has been debated for years, with prior meta-analyses yielding conflicting results.
- This study addresses the controversy by providing an updated systematic review and meta-analysis.
Purpose of the Study:
- To investigate the relationship between obstructive sleep apnea (OSA) and cancer incidence.
- To update previous meta-analyses and clarify the controversial association.
Main Methods:
- A systematic search of PubMed, Embase, and the Cochrane Library was conducted for studies on cancer and OSA.
- Data extraction and quality assessment were performed independently by two reviewers.
- Overall incidence of cancer in OSA patients and OSA in cancer patients was calculated.
Main Results:
- 22 articles involving over 32.1 million patients were included in this meta-analysis.
- The incidence of OSA in cancer patients was 46% (95% CI, 27-67%).
- Cancer prevalence was 1.53 times higher (95% CI, 1.01-2.31) in OSA patients compared to non-OSA individuals.
Conclusions:
- Obstructive sleep apnea (OSA) is highly prevalent in cancer patients.
- Individuals with OSA have an increased likelihood of developing tumors.
- The incidence of cancer in OSA patients appears to be related to the severity of OSA.
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